Integrating Strategic and Tactical Rolling Stock Models with Cyclical Demand

In the transportation industry, companies position rolling stock where it is likely to be needed in the face of a pronounced weekly cyclical demand pattern in orders. Strategic policies based on assumptions of repetition of cyclical weekly patterns set rolling stock targets; during tactical execution, a myriad dynamic influences cause deviations from strategically set targets. We find that optimal strategic plans do not agree with results of tactical modeling; strategic results are in fact suboptimal in many tactical situations. We discuss managerial implications of this finding and how the two modeling paradigms can be reconciled

Pricing and Product Mix Optimization in Freight Transportation

We propose improved pricing and market mix can improve the profitability of the freight transportation provider through the reduction of equipment repositioning costs. We hypothesize that because of complexities surrounding pricing and equipment repositioning costing, existing pricing strategies in freight transportation fail to fully consider these costs. We test this hypothesis in an applied setting in which Monte Carlo simulation captures the stochasticity of market conditions inherent in the problem. We use a heuristic to improve the nondifferentiable, discontinuous objective function. Our results from test cases show with high confidence that current prices are not optimal, as indicated by a strong correlation between recommended increases and decreases in market prices and the internalized repositioning costs. Our hypothesis is further supported by a high confidence that the obtained profit level distribution is significantly (statistically) higher than the current profit levels

Logistics Costs Based Estimation of Freight Transportation Demand

Many supply chain and fi nished goods distribution networks involve intercity freight transportation. Shipping customers secure transportation services by matching their requirements to available service in an effort to minimize their total logistics costs subject to service level constraints. Frequently, shippers' modal decisions are constrained by short-term capacity constraints restricting one of the available options, or gaps in shipper knowledge or carrier marketing programs. As a result, the observed traffic flows may not reflect the potential demand for the mode. Because the potential demand for a mode is not directly measurable, when planning road and rail capacity, governments and railroads cannot make accurate capacity planning decisions based on current traffic flows. The model developed here identifi es the potential demand for intercity full truckload and intermodal shipments over the most heavily utilized 75,000 shipment lanes in the western United States by estimating minimum total logistics costs by mode. These flows are compared with actual U.S. freight flows in order to determine the differences between observed flows and the model estimated potential demand. The results indicate potential demand for intermodal transportation is high; considerable freight volumes could be delivered with lower logistics cost by switching from truck to intermodal transportation. This evidence suggests that observed traffic flows and trends may not be a sound basis for planning freight transportation infrastructure in the United States

Logistics Costs Based Estimation of Freight Transportation Demand

Many supply chain and fi nished goods distribution networks involve intercity freight transportation. Shipping customers secure transportation services by matching their requirements to available service in an effort to minimize their total logistics costs subject to service level constraints. Frequently, shippers' modal decisions are constrained by short-term capacity constraints restricting one of the available options, or gaps in shipper knowledge or carrier marketing programs. As a result, the observed traffic flows may not reflect the potential demand for the mode. Because the potential demand for a mode is not directly measurable, when planning road and rail capacity, governments and railroads cannot make accurate capacity planning decisions based on current traffic flows. The model developed here identifi es the potential demand for intercity full truckload and intermodal shipments over the most heavily utilized 75,000 shipment lanes in the western United States by estimating minimum total logistics costs by mode. These flows are compared with actual U.S. freight flows in order to determine the differences between observed flows and the model estimated potential demand. The results indicate potential demand for intermodal transportation is high; considerable freight volumes could be delivered with lower logistics cost by switching from truck to intermodal transportation. This evidence suggests that observed traffic flows and trends may not be a sound basis for planning freight transportation infrastructure in the United States

Constraint Programming for Scheduling

Our goal is to introduce the constraint programming (CP) approach within the context of scheduling. We start with an introduction to CP and its distinct technical vocabulary. We then present and illustrate a general algorithm for solving a CP problem with a simple scheduling example. Next, we review several published studies where CP has been used in scheduling problems so as to provide a feel for its applicability. We discuss the advantages of CP in modeling and solving certain types of scheduling problems. We then provide an illustration of the use of a commercial CP tool (OPL Studio) in modeling and designing a solution procedure for a classic problem in scheduling. We conclude with our speculations about the future of scheduling research using this approach

IS Journal Quality Assessment Using the Author Affiliation Index

Research productivity is one means by which academic units attain legitimacy within their institutional milieu and make their case for resources. Journal quality assessment is an important component for assessing faculty research productivity. We introduce the Author Affiliation Index (AAI), a simple method for assessing journal quality, to the IS domain. Essentially, the AAI of a journal is the percentage of academic authors publishing in that journal who are affiliated with a base set of high-quality academic institutions. Besides explaining the AAI, we demonstrate its use with a set of well-known IS journals, discuss its rankings vis-à-vis those resulting from other methods, and provide an example of how the basic AAI approach can be modified by changing the base school set that is used to define journal quality. The AAI has a number of advantages. First, it is a simple, low cost and transparent method for assessing any journal given a base school set. Second, it provides a consistent ranking of journals, particularly of those beyond the top consensus journals where less consistency is achieved with other measures. Third, it enables new journals to be rapidly assessed against more established ones without the lags or costs of other measures. The AAI provides another indicator of journal quality that is different from surveys and citation analyses

Intra-Arterial Combination Therapy for Experimental Acute Ischemic Stroke

Acute ischemic stroke continues to devastate millions of individuals worldwide. Current treatments work to restore blood flow but not rescue affected tissue. Our goal was to develop a combination of neuroprotective agents administered intra-arterially following recanalization to target ischemic tissue. Using C57Bl/6J male mice, we performed tandem transient ipsilateral middle cerebral/common carotid artery occlusion, followed by immediate intra-arterial pharmacotherapy administration through a standardized protocol. Two pharmacotherapy agents, verapamil and lubeluzole, were selected based on their potential to modulate different aspects of the ischemic cascade; verapamil, a calcium channel blocker, works in an acute fashion blocking L-type calcium channels, whereas lubeluzole, an N-methyl-D-aspartate modulator, works in a delayed fashion blocking intracellular glutamate trafficking. We hypothesized that combination therapy would provide complimentary and potentially synergistic benefit treating brain tissue undergoing various stages of injury. Physiological measurements for heart rate and pulse distention (blood pressure) demonstrated no detrimental effects between groups, suggesting that the combination drug administration is safe. Tissue analysis demonstrated a significant difference between combination and control (saline) groups in infarct volume, neuronal health, and astrogliosis. Although a significant difference in functional outcome was not observed, we did note that the combination treatment group had a greater percent change from baseline in forced motor movement as compared with controls. This study demonstrates the safety and feasibility of intra-arterial combination therapy following successful recanalization and warrants further study

Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke

Background: Nitroglycerin (also known as glyceryl trinitrate (GTN)), a vasodilator best known for treatment of ischemic heart disease, has also been investigated for its potential therapeutic benefit in ischemic stroke. The completed Efficacy of Nitric Oxide in Stroke trial suggested that GTN has therapeutic benefit with acute (within 6 hours) transdermal systemic sustained release therapy. Objective: To examine an alternative use of GTN as an acute therapy for ischemic stroke following successful recanalization. Methods: We administered GTN IA following transient middle cerebral artery occlusion in mice. Because no standard dose of GTN is available following emergent large vessel occlusion, we performed a dose–response (3.12, 6.25, 12.5, and 25 .ig/.iL) analysis. Next, we looked at blood perfusion (flow) through the middle cerebral artery using laser Doppler flowmetry. Functional outcomes, including forced motor movement rotor rod, were assessed in the 3.12, 6.25, and 12.5 .ig/.iL groups. Histological analysis was performed using cresyl violet for infarct volume, and glial fibrillary activating protein (GFAP) and NeuN immunohistochemistry for astrocyte activation and mature neuron survival, respectively. Results: Overall, we found that acute post-stroke IA GTN had little effect on vessel dilatation after 15 min. Functional analysis showed a significant difference between GTN (3.12 and 6.25 .ig/.iL) and control at post-stroke day 1. Histological measures showed a significant reduction in infarct volume and GFAP immunoreactivity and a significant increase in NeuN. Conclusions: These results demonstrate that acute IA GTN is neuroprotective in experimental ischemic stroke and warrants further study as a potentially new stroke therapy

Intra-Arterial Nitroglycerin as Directed Acute Treatment in Experimental Ischemic Stroke

BACKGROUND: Nitroglycerin (also known as glyceryl trinitrate (GTN)), a vasodilator best known for treatment of ischemic heart disease, has also been investigated for its potential therapeutic benefit in ischemic stroke. The completed Efficacy of Nitric Oxide in Stroke trial suggested that GTN has therapeutic benefit with acute (within 6 hours) transdermal systemic sustained release therapy. OBJECTIVE: To examine an alternative use of GTN as an acute therapy for ischemic stroke following successful recanalization. METHODS: We administered GTN IA following transient middle cerebral artery occlusion in mice. Because no standard dose of GTN is available following emergent large vessel occlusion, we performed a dose-response (3.12, 6.25, 12.5, and 25 µg/µL) analysis. Next, we looked at blood perfusion (flow) through the middle cerebral artery using laser Doppler flowmetry. Functional outcomes, including forced motor movement rotor rod, were assessed in the 3.12, 6.25, and 12.5 µg/µL groups. Histological analysis was performed using cresyl violet for infarct volume, and glial fibrillary activating protein (GFAP) and NeuN immunohistochemistry for astrocyte activation and mature neuron survival, respectively. RESULTS: Overall, we found that acute post-stroke IA GTN had little effect on vessel dilatation after 15 min. Functional analysis showed a significant difference between GTN (3.12 and 6.25 µg/µL) and control at post-stroke day 1. Histological measures showed a significant reduction in infarct volume and GFAP immunoreactivity and a significant increase in NeuN. CONCLUSIONS: These results demonstrate that acute IA GTN is neuroprotective in experimental ischemic stroke and warrants further study as a potentially new stroke therapy

Convective Fingering of an Autocatalytic Reaction Front

We report experimental observations of the convection-driven fingering instability of an iodate-arsenous acid chemical reaction front. The front propagated upward in a vertical slab; the thickness of the slab was varied to control the degree of instability. We observed the onset and subsequent nonlinear evolution of the fingers, which were made visible by a {\it p}H indicator. We measured the spacing of the fingers during their initial stages and compared this to the wavelength of the fastest growing linear mode predicted by the stability analysis of Huang {\it et. al.} [{\it Phys. Rev. E}, {\bf 48}, 4378 (1993), and unpublished]. We find agreement with the thickness dependence predicted by the theory.Comment: 11 pages, RevTex with 3 eps figures. To be published in Phys Rev E, [email protected], [email protected], [email protected]